We Pee Navy Blue

Methylene Blue

Malaria, Alzheimers, mitigate adverse cancer treatment chemotherapeutic effects, UTIs, methemoglobinemia
>On the other hand, positive side effects of MB acting as
a tonic have also been observed; these effects are possibly
due to an enhancement of mitochondrial activity.

Since 2007, however, we have had
difficulties in obtaining sufficient MB from pharmaceutical
companies for the clinical trials in West Africa. In
Germany, MB is no longer available even in pediatric
emergency rooms (Ludwig and Baethge, 2010). In addition,
it was claimed that the available MB preparations
were not pure enough, the major contaminants being
heavy metals, azure B, and water. By contrast, we regard
the prevailing requirements of USP and EP (listed for
instance in http://www.provepharm.com/analysis.php) as appropriate.
Taking heavy metal ions as examples, copper
and chromium are essential nutrients, and it is interesting
to compare their contents in a daily MB dose with their
contents in the ingredients of a standard meal. As a
conservative physician one is often concerned about the
overblown safety requirements of postmodern medicine
which too often prevent health- or even life-saving measures.

MB is spontaneously
oxidized by molecular oxygen (O2) to give toxic
reactive oxygen species (ROS) like superoxide or hydrogen
peroxide while MB is formed again. In this way MB is
available for the next cycle; it acts — in a functional unit
together with flavoenzymes and molecular oxygen — as a
recycling catalyst against infectious organisms (Fig. 1).
Apart from medical applications, this is the basis for using
MB as a disinfectant (Clark et al., 1925), for example as a
fungicide in aquariums (see, e.g., http://www.americanaquariumproducts.com).
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.476.2623&rep=rep1&type=pdf

(“Even at the loo we see, we pee, navy blue”)-Ditty from WWII when used as anti-malaria drug

Salt, Sodium, Scapegoats

The “counter-factual” reality of salt consumption…

salt bacon

  • A high-salt diet will not increase your risk of heart disease. Having the correct potassium to sodium balance influences your risk for high blood pressure and heart disease to a far greater extent than high sodium alone

When the crew ate more salt, they excreted more salt; the amount of sodium in their blood remained constant, and their urine volume increased. ‘But then we had a look at fluid intake, and were more than surprised,’ he said.

Instead of drinking more, the crew were drinking less … when getting more salt. So where was the excreted water coming from? ‘There was only one way to explain this phenomenon,’ Dr. Titze said. ‘The body most likely had generated or produced water when salt intake was high.'”

The other puzzling finding was that the astronauts complained of being constantly hungry when given higher amounts of salt. Interestingly, urine tests revealed they were producing higher amounts of glucocorticoid hormones, which affect both your metabolism and immune function.

Follow-up animal testing confirmed the results, showing the more salt the mice were given, the less water they drank and the more food they required to avoid weight loss. The reason why then became apparent. As the salt intake increased, the animals produced higher amounts of glucocorticoid hormones, causing increased fat and muscle breakdown.

These broken-down muscle proteins are then converted into urea, which is known to help your body excrete waste via urine. Through some still-unknown mechanism, this urea also helps your body retain water. In other words, a side effect of higher salt consumption is that it frees up water for your body to use.

However, this process is energy-intensive, which is why the animals required more food when on a high-salt diet and why the astronauts complained of hunger. Titze believes the increase in glucocorticoid hormones are also somehow responsible for the bizarre cyclical fluctuations in urine output.

“Scientists knew that a starving body will burn its own fat and muscle for sustenance. But the realization that something similar happens on a salty diet has come as a revelation,” The New York Times reports.11

“People do what camels do, noted Dr. Mark Zeidel, a nephrologist at Harvard Medical School who wrote an editorial accompanying Dr. Titze’s studies. A camel traveling through the desert that has no water to drink gets water instead by breaking down the fat in its hump.

One of the many implications of this finding is that salt may be involved in weight loss. Generally, scientists have assumed that a high-salt diet encourages a greater intake of fluids, which increases weight. But if balancing a higher salt intake requires the body to break down tissue, it may also increase energy expenditure.”

As noted by Dr. Melanie Hoenig, nephrologist and assistant professor of medicine at Harvard Medical School, “The work suggests that we really do not understand the effect of sodium chloride on the body.”12

While salt has gotten a bad rap, suspected of increasing your risk for high blood pressure and heart disease, research shows the real key to relaxing your arteries and reducing your blood pressure is actually the ratio of sodium to potassium you have — not your sodium intake alone.13

>In 2007, the authors of the Third National Health and Nutrition Examination Survey (The NHANES III study) representing nearly 100 million US adults reported that there is “ a robust, significant, and consistent significant inverse association between dietary sodium and cardiovascular mortality.”2 This means people who eat more salt have a lower risk of death from heart disease and stroke.

Effective Diet Therapy

In 1939 Walter Kempner, MD introduced the rice diet for the treatment of serious medical problems, including severe hypertension, congestive heart failure, kidney failure, and diabetes at Duke University School of Medicine.19,20 In 2002 I visited the Rice Diet Clinic in Durham, North Carolina and compared notes with the doctors working at this famous facility (Dr. Kempner retired in 1992 and died in 1997 at age 94). Patients with many ailments have had their health restored with the Kempner diet of rice with fruit, and later on, vegetables and a few animal products. As a result of the pioneering work of Dr. Kempner, for almost 70 years diet therapy has been available for every doctor to cure his or her patients. The greatest obstacle to widespread deployment of this treatment has been the unfamiliar taste of the rice-based-meals due to preparation without any added salt. My 32 years of diet-focused medical experience has taught me that the major benefits of the rice diet are from the rice. Understanding that salt is not a health issue (except for the very ill) has allowed me to design a program that works for you and I for a lifetime, because it tastes good.

https://www.drmcdougall.com/misc/2008nl/aug/salt.htm

How to Cook Japanese Knotweed: A Szechuan Pork Stir-fry

Japanese Knotweed shoots can be cooked and eaten in many ways similar to rhubarb and asparagus.  The tart flavor is not as intense and more citric or lemony than rhubarb. The shoots can be easily peeled to remove the more fibrous outer layer or not. A post shared from another blog:

 

Kitchen Princess

Japanese knotweed stir-fry

The hipsters at Brooklyn Kitchen are NOT impressed with Japanese knotweed. It’s an invasive species! A pest! The sign says BEWARE! Still they feel the need to charge me $12.99 per pound but so it goes. A cute hipster guy in glasses behind me in line asked what it was and the cute hipster guy in glasses who was ringing me up said “It’s Japanese knotweed, it’s an invasive species.” Okay we get it.

Japanese knotweed at Brooklyn Kitchen

I asked how I should cook it and he told me to fry it with a little garlic. Usually I don’t trust attractive hipster men in glasses but I decided to take a chance and fry it with a little garlic. Turns out he was right! It’s delicious and to me tasted nothing like rhubarb as the sign had warned. I sautéed it with a little olive oil, garlic and lemon and it was stunningly delicious. Like…

View original post 343 more words

Bitter Medicine

Some herbal bitters are deliciously or pleasantly bitter especially when combined in traditional mixtures that offset the bitter with sugar for sweetness. Most Italian amaro liquors typically consumed as aperitivo or digestivo before or after meals are in that category.

amaro

http://www.drinkspirits.com/liqueur/what-to-drink-for-thanksgiving-aperitif-and-digestif/

Fernet Branca is over-the-top for most peoples tastes.

fernet_2654241b

Andrographis is a bitter herb that resembles in flavor Fernet Branca. If you have a respiratory problem you might want to try it.

Even modern pharmacology living in its new flat-earth bubble of unvalidated proxies, straw-men and no-true-Scotsman logical fallacies has come to recognize value in Andrographis:

“The anti-inflammatory effect of Andrographis paniculata(Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway

In this study, oral administration of APN showed significant anti-inflammatory activity in pathogen-induced PID rats, including suppressing the infiltration of neutrophils and lymphocytes and reducing excessive production of cytokines or chemokines. A potential mechanism of this effect was involved in inhibiting the activation of NF-κB pathway.”   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123283/

What, you object to being compared to a female rat? Try this study then:

Dehydroandrographolide enhances innate immunity of intestinal tract through up-regulation the expression of hBD-2

…However, DA has not been found to significantly inhibit bacterial and viral growth directly. The current study investigates the effect of DA on the expression of human β –defensin-2 (hBD-2) in human intestinal epithelial cells and the possible signaling pathways.

In summary, we have demonstrated that exposure of intestinal epithelial cells to DA caused the activation of a signaling cascade involving p38 MAPK up-regulation expression of hBD-2 in intestinal epithelial cells. This is one main reason why DA could be used for intestinal infection.”  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520058/

This study demonstrates that one constituent of Andrographis, DA, despite showing no direct antibacterial or antiviral effects does so indirectly via the gut associated lymph/immune system cells.

Defensins are a class of endogenous anti-microbial peptides, AMPs, active in animals and plants. Below is another example of AMP activity:

Antimicrobial peptides like human β-defensin-2 (HBD-2) play an important role in the innate immune system protecting the intestinal mucosa against bacterial invasion. The dietary histone deacetylase (HDAC) inhibitors sulforaphane (SFN) and butyrate have received a great deal of attention because of their ability to simultaneously modulate multiple cellular targets involved in cellular protection.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561129/

 

 

Got Lyme?

Sweet Annie, Sweet Stevia: The whole greater than the sum of its parts.

Artemisia annua L. (sweet wormwood, qinhao) has traditionally been used in Chinese medicine. The isolation of artemisinin from Artemisia annua and its worldwide accepted application in malaria therapy is one of the showcase success stories of phytomedicine during the past decades. Artemisinin-type compounds are also active towards other protozoal or viral diseases as well as cancer cells in vitro and in vivo. Nowadays, Artemisia annua tea is used as a self-reliant treatment in developing countries. The unsupervised use of Artemisia annua tea has been criticized to foster the development of artemisinin resistance in malaria and cancer due to insufficient artemisinin amounts in the plant as compared to standardized tablets with isolated artemisinin or semisynthetic artemisinin derivatives. However, artemisinin is not the only bioactive compound in Artemisia annua… This indicates that cells resistant to one compound retained sensitivity to another one. These results were also supported by microarray-based mRNA expression profiling showing that molecular determinants of sensitivity and resistance were different between artemisinin and the other phytochemicals investigated. https://www.ncbi.nlm.nih.gov/pubmed/21831619

Sweet Annie

Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?

Human trial data showed that when delivered as dried leaves, 40-fold less artemisinin was required to obtain a therapeutic response compared to pure artemisinin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323188/

>Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro

When Stevia and the three antibiotics were tested against attached biofilms, Steviasignificantly reduced B. burgdorferi forms. Results from this study suggest that a natural product such as Stevia leaf extract could be considered as an effective agent against B. burgdorferi.   https://www.ncbi.nlm.nih.gov/pubmed/?term=stevia+borrelia

The anti-borreliae efficacy of phytochemicals and micronutrients: an update        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971593/

Neuropathological evidence indicates that dopaminergic cell death in Parkinson׳s disease (PD) involves impairment of mitochondrial complex I, oxidative stress, microglial activation, and the formation of Lewy bodies. Epidemiological findings suggest that the consumption of berries rich in anthocyanins and proanthocyanidins may reduce PD risk. In this study, we investigated whether extracts rich in anthocyanins, proanthocyanidins, or other polyphenols suppress the neurotoxic effects of rotenone in a primary cell culture model of PD. Dopaminergic cell death elicited by rotenone was suppressed by extracts prepared from blueberries, grape seed, hibiscus, blackcurrant, and Chinese mulberry. Extracts rich in anthocyanins and proanthocyanidins exhibited greater neuroprotective activity than extracts rich in other polyphenols, and a number of individual anthocyanins interfered with rotenone neurotoxicity. The blueberry and grape seed extracts rescued rotenone-induced defects in mitochondrial respiration in a dopaminergic cell line, and a purple basal extract attenuated nitrite release from microglial cells stimulated by lipopolysaccharide. These findings suggest that anthocyanin- and proanthocyanidin-rich botanical extracts may alleviate neurodegeneration in PD via enhancement of mitochondrial function.https://www.ncbi.nlm.nih.gov/pubmed/24502982/

 

Ayurveda

How doctors cook the books and fry their patients…

The simplistic but flawed methods and logic, the level of denial in conventional medicine has become more obvious in recent years with the use of its own tools to quantify the immense differences between individuals related to epigenetics  and microbiomes unique to each organ and each person. Waving a magic wand called “Science” to cast a spell with the words “Evidence-Based”  or a curse with the words “Anecdotal” or “Quack” does not make their own fault go away. Evidence is everywhere, the critical issue is how to use it.

Rumi voice

3 Peas in a Pod. Proxies + Populations -> p (a measure of confidence or certainty in statistical abnalysis.) Years later many proxies (cholesterol for example) are found to be valid only within severely limited populations and circumstances. Furthermore, the confidence value p is only retroactive for the particular population included in the study. So no matter how large the population (often referred to as N) and no matter how high the calculated value of p for the measured results within that population, the application of that intervention in prescribing treatment or medication to any individual prospectively is uncertain. At best p is a lead, a clue.

An article in a magazine by an MD psychiatrist points out the fallacy in medical fields of so-called scientific methods when the model is the obsolete simplistic science of Newton. Physics and science now encompass Quantum Mechanics and General Relativity with integral and fundamental uncertainties, singularities and non-linearities that were inconceivable in Classical Physics.

“The fault belongs to who speaks it.”-Yunus Emre

The Gambler’s Fallacy is to believe the weight of statistics can be applied to a single incident or individual. (For example, if a gambler has won a big payout on a slot machine he/she will go to another machine to continue playing. Or, if there has been a series of tails the gambler will favor heads in betting if he/she believes the game to be truly random.) The MD’s fallacy in turn is to believe that a study with N=Bigly guarantees or proves something for N=1, that huge studies mean a high level of certainty for any one patient.

The “No True Scotsman Fallacy” is to introduce a judgmental qualifying adjective or criterium which the proponent can redefine to suit his own purposes. For example qualifiers such as True or Evidence-Based or Scientific.

Literally, Ayurveda means the science of life. But, the science of life is more than which herb to use or which food to eat for dinner – it’s a new way of thinking altogether.

Everyone needs medical doctors occasionally, but one’s quality of life comes from daily living. In a health context, Ayurveda allows you to easily match a person with what is good for them in a systematic yet highly individual way. Ayurveda recognizes the natural world as the means to basic wellness. Ayurveda offers a methodical model to approach the natural world as medicine in your day to day life, which can be used by all.

Ayurveda is an objective method of analysis like science, but based on qualifying individual experiences and patterns in nature instead of quantifying them, as science does. Instead of summarizing natural events with statistical averages alone, Ayurveda can switch between statistical models and highly individualized models for assessment with ease. It can be used alongside the scientific method in a variety of situations such as recovering from chemotherapy. Ayurveda even seems at ease navigating the highly individualized effects of chemotherapy. A diet of easy to digest foods that takes the person’s body type into account will enable them to rebuild their digestion (and health) more effectively.

Ayurveda recognizes that all of life is a relationship. In breaking down the dynamics of relationships, Ayurveda offers a model for interactions that predicts how your body will respond to contact with your environment. In addition to describing interactions, Ayurveda helps people describe sensations they are having and puts their experiences into a context, so you can see how the pieces fit with the whole.   http://www.joyfulbelly.com/Ayurveda/article/Why-Ayurveda-is-a-Crucial-New-Way-of-Thinking/5880

Evidence-Based medicine in action:

MD: “You tested negative for Lyme Disease.”

Patient: “Given the symptoms wouldn’t it be better risk/cost management to prescribe the usual antibiotics?”

MD: “You don’t have Lyme Disease therefore it is unethical to prescribe antibiotics.”

Patient: “You said I don’t have Lyme, but a negative test does not prove it. What are the percentage false negative and false positive for that test? I read at least 20% for each.”

MD: “The CDC prohibits prescribing antibiotics unnecessarily because of the growing threat of antibiotic resistant infections.”

Patient: “Is that more about the millions of pounds of antibiotics entering the food chain and the environment from agriculture practices?”

On the same topic, Lyme Disease:

A significant contributing challenge is the disease is notoriously difficult to diagnose using lab testing. The bacteria is able to infect your white blood cells. Testing measures the antibodies white cells produce, but infected cells don’t respond appropriately. Antibodies to the disease appear only after your white cells are functioning normally. This means that to get an accurate blood test, you first have to undergo treatment.16 To overcome this challenge, the CDC recommends a two-step testing process.17 

It is also interesting to note that the stevoside extract, by itself, was not found to be an effective antimicrobial agent against B. burgdorferi; nor did it have any effect on resistant cells.  Mass market stevia products, including Coca-cola’s Truvia (ironic branding, considering it does not have the truly therapeutic property of whole stevia), would not, therefore, have the medicinal property associated with the whole herb extract. This speaks, of course, to the well known principle in natural medicine that the activity of the whole can not be reproduced through a part, nor is the therapeutic activity of the whole identical to that of the sum of its parts. http://www.healthnutnews.com/study-shows-stevia-kills-lyme-disease-pathogen-better-than-antibiotics/

 

 

Bad Dogs Need Focus

BDNF-big dogs need food?

Buddha Does Not Flinch! And how to increase your own unflinching “Buddha,” brain derived neurotrophic factor, that is.

What’s on your mind, Facebook asks? BDNF! It is on my mind and in my mind. Yours too, the more the better. BDNF is a trending proxy-a metric for ways to improve mental health and brain function in Baby Boomers.

rumi-u-r-what-u-think

Exogenous BDNF treatment significantly improved neuromuscular transmission in all groups and NMTF in McAb3-treated rats was no longer different from control or McAb1-treated animals. We conclude that BDNF improves neuromuscular transmission in adult myasthenic rats. http://www.fasebj.org/content/24/1_Supplement/1064.13.short

A grab-bag of related info from ergo-log.com:   >BDNF does to brain cells pretty much what steroids do to muscle cells. It helps them grow – not in physical size, but by helping brain cells to make new connections with each other.

>BDNF enables brain cells to grow and form new connections, so that the brain can absorb new information. DHA boosted the concentration of BDNF, and yes, this increase was larger when combined with exercise.
“The protective effects associated with elevations in brain carnosine appear to be related to a protection of BDNF expression in the hippocampus”, the researchers concluded. “The precise mechanism of how elevated carnosine concentrations support BDNF expression requires additional research. This appears to be the first study known to demonstrate a potential role of bèta-alanine as a dietary supplement for the treatment or prevention of post-traumatic stress disorder.”

rumi noah

Paradoxically, perhaps, nicotine increases BDNF. >Although nicotine has been shown to improve cognitive function in various studies, the mechanisms underlying acute nicotine treatment-induced neuroprotection remain incompletely understood.  https://www.ncbi.nlm.nih.gov/pubmed/26259694

Considering the multifactorial nature of the biochemical links between physical activity and neurophysiology it is likely that there are many pharmacological mechanisms by which the beneficial actions of exercise can be effectively reproduced using chemical agents. Most studies to date have focused on brain-derived neurotrophic factor (BDNF) as a signaling target for the enhancement of neuronal function by exercise.

Understanding the molecular targets for exercise-induced regulation of neuroplasticity may lead to the development of novel therapeutic treatments for psychiatric and neurodegenerative disorders.

bdnfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821702/

>Based on our current findings, we anticipate that fucoxanthin might exhibit
great therapeutic efficacy for the treatment of Alzheimer’s disease by acting on multiple targets,including inhibiting AChE and increasing BDNF expression.   file:///root/Downloads/marinedrugs-14-00067.pdf

More grab-bags or call them tool boxes:

http://drjohnday.com/10-ways-to-boost-brain-function-with-bdnf/

https://selfhacked.com/2015/06/27/a-comprehensive-list-of-natural-ways-to-increase-bdnf/#DietFoods_to_Increase_BDNF

https://www.naturalstacks.com/blogs/news/76618565-why-bdnf-is-miracle-gro-for-your-brain

Linking brain and gut health:

http://www.sciencedirect.com/science/article/pii/S0304394016300775

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

Microsoft Word - Butyrate Review Final Revisions_V2.docx

 

 

Coffee Fruit, Caffeine, Nicotine, WTH?

The cigarette smokers’ Paradox

Separate the signal from the noise, the wheat from the chaff:

BDNF, brain derived neurotrophic factor, is good.

Telomerase is good. *(See telomeres, telomerase, aging and disease note below)

Nicotine is good… since nicotine is known to increase blood levels of BDNF(53)

tobacco1

Tobacco Plants, Nicotiana

*>Age is the highest risk factor for some of the most prevalent human diseases, including cancer. Telomere shortening is thought to play a central role in the aging process in humans. The link between telomeres and aging is highlighted by the fact that genetic diseases causing telomerase deficiency are associated with premature aging and increased risk of cancer. Telomeres are crucial for genome stability: they prevent chromosome ends from engaging in illegitimate repair and ensure their maintenance by recruiting the enzyme telomerase, a reverse transcriptase that elongates telomeres (de Lange, 2005). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958310

There has long been a question or so-called paradox related to the high levels of known toxins in cigarette smoke. As bad as cigarette smoking is for health, you might expect it to be much, much worse!

WTH! “Past and current smokers were less likely to develop cognitive impairment during a 10-year follow-up than were those who had never smoked. The present study suggests that smoking may be protective for cognitive function.”

But I will stick to rubbing fresh tobacco leaf juice on my skin for my nicotine fix…

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/div-classtitlemodulatory-effect-of-coffee-fruit-extract-on-plasma-levels-of-brain-derived-neurotrophic-factor-in-healthy-subjectsdiv/8B291E8D053143AA5A8D33B65496B034/core-reader

Nevertheless, the present work suggests that procyanidins may have the ability to increase plasma BDNF levels and, perhaps, to a larger extent than caffeine itself. This is particularly interesting considering that recent research show that procyanidin oligomers play a role in neuroprotection from excitotoxic injury(50).

BDNF-dependent telomerase activity has been shown to promote neuron survival in developing hippocampal neurons(51). Increased BDNF expression and telomerase activity after brain injury suggest that telomerase may play a role in BDNF-mediated neuroprotection. Furthermore, BDNF has been shown to up-regulate telomerase expression and activity in spinal motor neurons(52). These neurons, treated with BDNF, are more resistant to ex-cytotoxic injury, presumably from increased cellular resistance to apoptosis. It is interesting to speculate that WCFC possibly may also exert an anti-apoptotic effect through telomerase by increased BDNF activity.

WCFC was tested under experimental conditions reducing impact of possible confounding effects; for example, non-smokers were not included in the present study, since nicotine is known to increase blood levels of BDNF(53). All subjects remained in the clinical site during the duration of the study to avoid any shifts in blood level of BDNF due to exercise and physical activity(34).

The final reference in the article above:

The relationship between cigarette smoking and cognitive impairment is not a simple one. Some studies have demonstrated that cigarette smoking is a risk factor for cognitive impairment in the elderly, whereas other studies have shown cigarette smoking to be protective against dementia.

The possible “hinge factor” could be nicotine.

500 years ago, as Monardes wrote in “Joyfull News out of the New Found World,” tobacco among other “discovered” medicinal plants was considered to be a cure-all, a panacea.

https://everythingiknowaboutthatilearnedfrommysleddogs.wordpress.com/2016/06/30/red-hair-freckles-alert/

Bonus Marilyn Monroe sighting!

 

 

 

Third Brother Angus

I was thinking what kind of herbal tea to hydrate sprouting and malting seeds like broccoli, wheat, fenugreek, mung beans and desi chick peas to encourage growth and prevent mold. Malting, that means growing long enough to increase the phyto-nutrients to optimum concentration, usually 3-4 days and less than half inch sprout. Growing longer is a multiple liability, diluting the healthiest products of early germination for the sake of chlorophyll in emerging leaves: not the best reason to grow sprouts. You want chlorophyll? Eat spinach, spirulina, chlorella, etc. You want glucosinolates or whatever the major attraction in broccoli sprouts? Harvest them at 3-4 days max.

I already use willow bark, oak bark, horsetail. I only rinse sprouting seeds the first time, shaking the closed jar with enough water to cover the seeds thereby knocking loose any coating or harmful dust or spores on their surface then filling the container and draining all that readily comes off. After that it is hermetic, “hermetic sprouting,” in re-purposed pint glass salsa jars. Frequent rinsing involves a trade-off with a delicate balance of more risks than advantages, often causing mold because by keeping the seeds constantly wet with frequent exposure to spores floating in the air especially during the warm seasons. My method involves an optimum minimum necessary but sufficient hydration of the sprouting seeds.

angus-web-1

Then I was thinking about a quote from the Turkish TV series Yunus Emre: “If there were three brothers, Cain would have the other one do it.”

Trinity, threesome, trifecta, hat trick!

Glycerol is a triol, three valent alcohol. Shouldn’t it have anti-fungal and anti-mold activity? Bingo!

In a dual culture assay, the degree of inhibition of the molds was strongly enhanced by an increase in glycerol concentrations, while the yeast was less affected. In broth cultures, decreased pH in glycerol medium was probably responsible for the complete inhibition of the indicator fungi. NMR spectra of the glycerol conversion confirmed that propionic acid was the dominant metabolite. Based on the results obtained, the increased antifungal effect seen by glycerol addition to cultures of propionibacteria is due to the production of propionic acid and pH reduction of the medium. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038612/

Tangentially, a study supplementing cows’ diet with glycerol found bottom line benefits for production.

Supplementing cattle diets with crude glycerin and soybean oil can boost the nutritional quality of beef and block saturated fatty acid generation, research shows. The researchers found a link between the additions and a less bio-hydrogenation of unsaturated fatty acids, as well as better duodenal flow of fatty acids, resulting in “an immediate improvement on the fatty acid (FA) profile of meat and milk.” http://www.feednavigator.com/R-D/Can-crude-glycerin-soybean-oil-improve-the-nutritional-quality-of-beef

The effects are thought to be related to changes in rumen microbial activity. Increased propionate vs. butyrate and lactate generation is associated with healthy cows vs. more favorable butyrate increase in humans. Endogenous butyrate is considered to be the preferred energy source for colonocytes in humans and dogs. What is best for poultry?

chickenlittle2_new-1024x596

 

 

Puts A Double-Whammy On Cancer

(In the words of the article below)

What the goddess of Aspirin, Guanyin, and horse nuggets have in common.

The bottom line at the top, summarizing easily adopted, simple, prevention, therapy, and treatments, especially for dreaded colorectal cancers: NAD+, Niacin, Butyrate, Psyllium, Flax, seem to work together in parallel or complementary fashion. Butyrate is not something you can or would want to buy. Metabolism produces butyrate and analogues as “ketones” for energy when fasting or on a low carbohydrate diet. “Ketogenic diets.” Butyrate and diacetyl, a similar four carbon molecule, at low levels contribute to desirable flavors in cottage cheese, beer and other fermented foods. Butyrate is named for butter where it was first identified in the form of tributyrin, the triglyceride ester, a molecule of glycerol with three butyrates attached.

“The dose makes the poison.”-Paracelsus

Don’t freak out! Butyric acid is the smell of vomit (retrograde intestinal action in emesis/vomiting demonstrates its importance and relatively high presence in the gut) but because butyrate exists in the form of triglyceride in foods only a small amount is present as free fatty acid. And “ketones,” the healthy levels from fasting and ketogenic diets are an order of magnitude lower ~one tenth the amounts resulting from diabetic ketoacidosis.

It’s not the germ, it’s the host/terrain/milieu!-Bernard vs. Pasteur

In the book, The Stress of Life (Mc Graw-Hill, 1956), Dr. Hans Selye, the foremost authority on stress and its effect on the human system, writes: “Let me point out here parenthetically that Pasteur was sharply criticized by many of his enemies for failing to recognize the importance of the terrain (the soil in which disease develops). They said he was too one-sidely preoccupied with the apparent cause of disease: the microbe itself. There were, in fact, many debates about this between Pasteur and his great contemporary, Claude Bernard: the former insisted on the importance of the disease-producer, the latter on that of the body’s own equilibrium. Yet Pasteur’s work on immunity induced with serums and vaccines shows that he recognized the importance of the soil. In any event, it is rather significant that Pasteur attached so much importance to this point that on his deathbed he said to Professor A. Renon who looked after him: “Bernard avait raison. Le germe n’est rien, c’est le terrain qui est tout.” (“Bernard was right. The microbe is nothing, the soil is everything.”)

http://www.rethinkingcancer.org/resources/magazine-articles/5_3-4/are-germs-the-real-problem.php

Stress is like a lever, and current physiological and mental state, the terrain, establish the position of the fulcrum for better and worse, determining how much functional advantage or disadvantage stress has in the final result. Eustress is the level of stress that stimulates growth and health. Distress is excess stress with net harmful effects. The factor determining whether stress is good or bad may often be the mental state of the subject at the outset of the trial.

The first article below focuses on the immediate source of butyrate, that produced by bacteria in the gut from dietary fiber. The most studied amplifier of butyrate gut levels is psyllium husk which seems to increase production by itself and leveraging other fiber, as well as the microbe populations that generate butyrate. Not to exclude the possibility of other foods or fibers with similar or even greater effects. But the market for constipation relief has driven research, and the collateral heart health benefits discovered from psyllium husk products like Metamucil have partly determined the targets and results.

Psyllium husk is the seed coat of plantain/plantago species, the common garden weed. The pure seed coat has a bland slightly bitter taste. In gluten-free baked foods, breads and dough the bitterness contributes a desirable flavor replacing something lost when wheat is excluded.

Psyllium and ground flax can be added to porridge or pancakes or bread without compromising taste. In dishes using ginger or pumpkin pie/chai tea/gingerbread spices it’s a slam dunk. Organic whole flax seed has good storage life until ground. Buy one or several electric coffee grinders, typically ~$15 new, to use for grinding flax and many herbs and spices. Psyllium seed husk does not need pulverizing to be effective, flax does.

https://www.sciencedaily.com/releases/2009/04/090413141259.htm
Researchers report in the April issue of Cancer Research that the GPR109A receptor is activated by butyrate, a metabolite produced by fiber-eating bacteria in the colon. The receptor puts a double-whammy on cancer by sending signals that trigger cell death, or apoptosis, and shutting down a protein that causes inflammation, a precursor to cancer.

More about flax: https://www.ncbi.nlm.nih.gov/pubmed/21390942

Whole rye may have effects similar to flax, sharing at least one common constituent which produces enterolactone or enterodiols.

What is the role of grapefruit in ketogenic diets?  http://www.livestrong.com/article/480028-the-three-day-aha-diet/

http://www.life-enhancement.com/magazine/article/3609-ketones-the-new-fast-energy-revolution-part-ii

http://www.life-enhancement.com/magazine/article/3594-medium-chain-triglycerides-mcts-and-the-ketogenic-diet

List of some foods and dietary supplements with alleged or extrapolated anti-cancer effects: NAD+, Niacin, Beta-Alanine, Flax, Rye, endogenous butyrate production increased by psyllium, butyrate in butter…

https://selfhacked.com/2016/12/27/nad-important-increase/

Whole real foods… what is not real or natural about psyllium, the seed husk of plantain? (Plantago species, not banana-like plantain) That Metamucil is the commercialized version with added sugar or artificial sweetener and/or orange flavor does not detract from the pure herbal food which has been used for centuries and likely millennia. A copy of Culpeper’s Complete Herbal date 1563 lists the seed as useful for several conditions. The seeds are and have been used for food and medicine going back to ancient times. The husk or seed coat of many seeds has food and medicine value but often discarded. Buckwheat hulls are added back into the flour for flavor and color but it’s now recognized that they increase the nutritional/health value.

As mentioned above, psyllium has been found in studies to increase butyrate production in the gut. It does not require much to have an effect. A heaping teaspoon of psyllium will quickly turn a glass of water into gel. Perhaps in part the dietary fiber effects are due to the increase in viscosity of digesta, entraining other foods that are usually otherwise digested higher up in the GI tract, turning digestible carbs into resistant carbs.

Dietary fiber is a broad classification that does not tell you much by itself. Soluble, insoluble, fermentable, non-fermentable? Specific varieties of polysacharides, beta glucans, have been studied and classified according to the locations of the glucose-glucose linkages and their health/immune support effects.  https://en.wikipedia.org/wiki/Beta-glucan

The dose makes the poison, wrote the “Father of Toxicology,” Paracelsus. The dose makes the medicine. The dose makes the difference. But only by interacting with the individual host, terrain, milieu. For example, glucose, the common blood sugar, is a reactive aldehyde. Even at moderate levels the reactions with proteins that cause glycosylation or Maillard browning on the crust of bread also cause proteins in the body to be denatured and inactivated. However, at moderate levels metabolism can detoxify and dispose of these. That is what hemoglobin A1c tests are about with diabetics. To say “moderate” is using the No True Scotsman logical fallacy. If there are bad effects then the levels are not moderate. Moderate or not moderate depends on the host.

Chemical reactions go in both directions. OH + H > H2O  Water is fairly stable and the potential energy of the H-OH bond drives the reaction strongly toward H2O. But not totally! That is what equilibrium constants, the mass action principle and pH tell you. So too with ketone and ketone bodies, hydroxybutyrate and acetoacetate. Acetoacetate becomes acetone spontaneously in the body but the ratio of acetone to the “ketone bodies” is low but not negligible. So too with the esterification/hydrolysis reaction glycerol + butyric acid = tributyrin.

>The heart preferentially utilizes fatty acids as fuel under normal physiologic conditions. However, under ketotic conditions, the heart can effectively utilize ketone bodies for this purpose.[9]

The brain gets a portion of its fuel requirements from ketone bodies when glucose is less available than normal (e.g., during fasting, strenuousexercise, low carbohydrate, ketogenic diet and in neonates). In the event of a low glucose concentration in the blood, most other tissues have alternative fuel sources besides ketone bodies and glucose (such as fatty acids), but the brain has an obligatory requirement for some glucose.[10]After the diet has been changed to lower blood glucose utilization for 3 days, the brain gets 25% of its energy from ketone bodies.[11] After about 4 days, this goes up to 70%[12] (during the initial stages the brain does not burn ketones, since they are an important substrate for lipid synthesis in the brain). Furthermore, ketones produced from omega-3 fatty acids may reduce cognitive deterioration in old age.[13] 

The process of ketosis is currently being investigated for efficacy in ameliorating the symptoms of Alzheimer’s disease.[15]   https://en.wikipedia.org/wiki/Ketone_bodies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084248/

http://www.plefa.com/article/S0952-3278(06)00090-1/abstract  Brain DHA level seems to be an important regulator of brain glucose uptake, possibly by affecting the activity of some but not all the glucose transporters. DHA synthesis from either α-linolenic acid (ALA) or eicosapentaenoic acid (EPA) is very low in humans begging the question of whether these DHA precursors are likely to be helpful in maintaining cognition during aging. We speculate that ALA and EPA may well have useful supporting roles in maintaining brain function during aging but not by their conversion to DHA. ALA is an efficient ketogenic fatty acid, while EPA promotes fatty acid oxidation. By helping to produce ketone bodies, the effects of ALA and EPA could well be useful in strategies intended to use ketones to bypass problems of impaired glucose access to the brain during aging. Hence, it may be time to consider whether the main omega-3 fatty acids have distinct but complementary roles in brain function.

https://authoritynutrition.com/19-best-prebiotic-foods/

Note konjac root used in Japan for shirataki noodles.