“It’s an ill wind that blows no good”
On the anniversary of Donald Trump’s 2017 inauguration the CDC is reducing their fear-mongering protection racket activities because of the government budget shutdown.
They won’t be able to continue pushing the self-serving and Big Pharma agenda for hyper-vaccination, apocalipstick flu-phobia and general eco-phobia, they won’t be trumpeting the straw man fallacy that people with persistent symptoms after Lyme disease are hypochondriacs because no Borrelia are found.
Fortunately there are Alternative Medicine methods and substances! In medicine as in biology, diversity is strength. Monoculture leads to distress and dysfunction.
Further studies in ceftriaxone-treated infected mice have shown that Borrelia
infections in mice can have a resurgent pattern. The treated mice tested consistently negative for Borrelia through microscopy, culture, xenodiagnoses and PCR from 1 to 8 months after infection.
However, the presence of non-culturable Borrelia was discovered in treated mice 12 months after infection through PCR. At month 12, the levels of Borrelia flaB DNA in the treated mice were similar to the levels found in the saline-treated infected control group.
These results suggest that Borrelia actually replicated after antibiotic removal in a form that is not culturable and that mice may be used as a viable model for long-term treatment study of PTLDS.
The commonly used Lyme antibiotics have been found to be highly effective
against actively growing log phase Borrelia cultures, but have little activity against stationary phase populations.
In order to address this issue, I chose to examine 13 drugs that were orally
bioavailable, had low toxicity, and were previously shown to have high activity against
stationary phase Borrelia populations (<60% viable cells remaining after antibiotic
exposure). These drugs were tested both in double and triple drug combinations in order to study the effects of a combinatorial approach to Borrelia antibiotic treatment.
However, the recommendation against the use of drug combinations for Lyme disease is based primarily on lack of proven efficacy and toxicity concerns, which I have addressed in this study through the use of low toxicity drugs that are frequently used effectively in combination for other diseases.
Methylene blue is the only drug that in the screen with high activity against both
stationary phase and persistent populations. Methylene blue is a photosensitive dye once used as an antimalarial that produces free radicals and hydroxides when exposed to light.
Here, we evaluated the activity of 34 essential oils against B. burgdorferi stationary phase culture as a model for persister bacteria. We found that not all essential oils had activity against the B. burgdorferi stationary phase culture, with top five essential oils (oregano, cinnamon bark, clove bud, citronella, and wintergreen) at a low concentration of 0.25% showing high anti-persister activity that is more active than the known persister drug daptomycin. Interestingly, some highly active essential oils were found to have excellent anti-biofilm ability as shown by their ability to dissolve the aggregated biofilm-like structures. The top three hits, oregano, cinnamon bark, and clove bud completely eradicated all viable cells without any regrowth in subculture in fresh medium, whereas but not citronella and wintergreen did not have this effect.