Shut Your Mouth!

And don’t believe everything you think…

Short clip from the end of the film. Henry Fonda is Jack Beauregard:

As a trick or joke it goes back at least to The Odyssey, the Cyclops shouts for help: “Nobody is trying to kill me!”
Then more recently in the Sergio Leone Spaghetti Western, My Name Is Nobody. After the final shootout the inscription on on the loser’s grave marker reads, JACK BEAUREGARD 1848-1899 NOBODY WAS FASTER ON THE DRAW
Here’s a new spin on the meme: “NO gas from the nose and sinuses is inhaled with every breath”

>The discovery within the paranasal sinuses for the production of nitric oxide (NO) has altered the traditional explanations of sinus physiology. This review article reports the ongoing investigation of sinus physiology beginning with the discovery of NO gas production in the paranasal sinuses that occurred in 1995, and the impact that finding has had both in the basic science and clinical arenas. It was shown that healthy paranasal sinus epithelium expresses an inducible NO synthase that continuously generates large amounts of NO, a pluripotent gaseous messenger with potent vasodilating, and antimicrobial activity. This NO can be measured noninvasively in nasally exhaled breath. The role of NO in the sinuses is likely to enhance local host defense mechanisms via direct inhibition of pathogen growth and stimulation of mucociliary activity. The NO concentration in a healthy sinus exceeds those that are needed for antibacterial effects in vitro. In patients with primary ciliary dyskinesia (PCD) and in cystic fibrosis, nasal NO is extremely low. This defect NO generation likely contributes to the great susceptibility to chronic sinusitis in these patients. In addition, the low-nasal NO is of diagnostic value especially in PCD, where nasal NO is very low or absent. Intriguingly, NO gas from the nose and sinuses is inhaled with every breath and reaches the lungs in a more diluted form to enhance pulmonary oxygen uptake via local vasodilation. In this sense NO may be regarded as an “aerocrine” hormone that is produced in the nose and sinuses and transported to a distal site of action with every inhalation. (https://www.ncbi.nlm.nih.gov/pubmed/18951492)
More reason to heed George Catlin and Weston Price’s advice to Shut Your Mouth! (breath through your nose)

>There is accumulating evidence that nasal humming (which is the production of a tone without opening the lips or forming words) during nNO measurement increases nNO levels due to a rapid gas exchange in the paranasal sinuses. (https://www.ncbi.nlm.nih.gov/pubmed/23547821)

>This suggests that flavones may have anti-gram-negative potential as topical therapeutics when combined with antibiotics or in the context of innate antimicrobials secreted by the respiratory or other epithelia. This may have an additive effect when combined with T2R14-activated NO production. Additional studies are necessary to understand which flavone compounds or mixtures are the most efficacious. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607194/)

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Put The Lyme In The Coconut

“It’s an ill wind that blows no good”

On the anniversary of Donald Trump’s 2017 inauguration the CDC is reducing their fear-mongering protection racket activities because of the government budget shutdown.

They won’t be able to continue pushing the self-serving and Big Pharma agenda for hyper-vaccination, apocalipstick flu-phobia and general eco-phobia, they won’t be trumpeting the straw man fallacy that people with persistent symptoms after Lyme disease are hypochondriacs because no Borrelia are found.
Fortunately there are Alternative Medicine methods and substances! In medicine as in biology, diversity is strength. Monoculture leads to distress and dysfunction.

Further studies in ceftriaxone-treated infected mice have shown that Borrelia
infections in mice can have a resurgent pattern. The treated mice tested consistently negative for Borrelia through microscopy, culture, xenodiagnoses and PCR from 1 to 8 months after infection.

However, the presence of non-culturable Borrelia was discovered in treated mice 12 months after infection through PCR. At month 12, the levels of Borrelia flaB DNA in the treated mice were similar to the levels found in the saline-treated infected control group.

These results suggest that Borrelia actually replicated after antibiotic removal in a form that is not culturable and that mice may be used as a viable model for long-term treatment study of PTLDS.

The commonly used Lyme antibiotics have been found to be highly effective
against actively growing log phase Borrelia cultures, but have little activity against stationary phase populations.

In order to address this issue, I chose to examine 13 drugs that were orally
bioavailable, had low toxicity, and were previously shown to have high activity against
stationary phase Borrelia populations (<60% viable cells remaining after antibiotic
exposure). These drugs were tested both in double and triple drug combinations in order to study the effects of a combinatorial approach to Borrelia antibiotic treatment.

However, the recommendation against the use of drug combinations for Lyme disease is based primarily on lack of proven efficacy and toxicity concerns, which I have addressed in this study through the use of low toxicity drugs that are frequently used effectively in combination for other diseases.

Methylene blue is the only drug that in the screen with high activity against both
stationary phase and persistent populations. Methylene blue is a photosensitive dye once used as an antimalarial that produces free radicals and hydroxides when exposed to light.
(https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/39473/WEITNER-THESIS-2016.pdf)

Here, we evaluated the activity of 34 essential oils against B. burgdorferi stationary phase culture as a model for persister bacteria. We found that not all essential oils had activity against the B. burgdorferi stationary phase culture, with top five essential oils (oregano, cinnamon bark, clove bud, citronella, and wintergreen) at a low concentration of 0.25% showing high anti-persister activity that is more active than the known persister drug daptomycin. Interestingly, some highly active essential oils were found to have excellent anti-biofilm ability as shown by their ability to dissolve the aggregated biofilm-like structures. The top three hits, oregano, cinnamon bark, and clove bud completely eradicated all viable cells without any regrowth in subculture in fresh medium, whereas but not citronella and wintergreen did not have this effect.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641543/)

One MD’s take on Lyme:

“Lyme disease isn’t something that anyone would ever wish for. It changes everyone it touches. It can leave you broken and bitter.

Ten years of my life were robbed by my encounter with chronic Lyme disease. I lost my profession, my social community, and even my passion for life. Everything had to be rebuilt.

Oddly, despite those losses, I’m a better person for having experienced Lyme disease.

Lyme disease is the ultimate teacher. I learned more about overcoming chronic illness in the years I struggled with Lyme disease than I learned in all of medical school and 20 years of medical practice.

I also learned about myself. But it didn’t just happen to me — I had to make it happen for myself.”

Mushing Is Not Skiing

Sleds are not skis.

Tim Alpirod 1

Outside foot on the inside (of the turn radius) runner, inside foot on the ground beyond the inside runner.

Tim IRMSSSDR

I made and sold sleds from 1977 until around 1998. Hundreds of sleds. None of them were laterally flexible. The plastic bed toboggan sleds had aluminum cross brace between the rear stanchions. The Aero sleds with plastic tunnel bed, no wooden parts, aluminum runners, the driving bow was a single piece combination driving bow and stanchions made of aluminum tube or rod. Rigid laterally. If you caught the outside edge/runner it could throw you out or off, but only if your weight was high and you did not shift your weight to lean into turns and side hills. The photos show how. Get Down! Schwarzenegger the actor says in a role in the movies.

With a heavy load, a person or cargo, if the sled runners tilt too easily and the load shifts, it will steer the sled beyond/out of the driver’s control, usually in the wrong direction, sideways down a hill or to the outside of a turn. Positive feedback with negative effects can be catastrophic.

I see many photos of sprint races with traditional basket sleds and newer so-called improved designs that have more sideways flexibility than the pictured Aero sled but the runners are in this same position and the outside runner is partly in the air going around corners on the trail. Because dog sledding is not downhill skiing! The ski instructor tells you to lean into a turn, put your weight on the outside or downhill ski and close the distance between the two skis. The sled runners are a constant distance apart and for mushing you put your weight on the uphill or inside runner. In one of the best mushing videos of my collection, 1993 Alpirod, Deedee is explaining this but got it backwards. “Do as I do, not as I say.” If you lean into a turn which runner will you put your weight on?

This is the best way to balance, to be stable around a corner with a sled having runners 50 cm apart (not like XC or downhill skis that you can bring close together) The exception trail condition is side hill (devers in French) on hard icy surface, or worse, bare pavement. I never encountered this condition in all the years racing in USA and Canada and Alaska and Argentina. In Europe I never encountered this condition except a few times on particular corners in Alpirod, but the rigid sled worked fine.  If you can edge/cant runners on ice you may loose control when you edge too much or hit a bad spot, or if you count on the runner edge and don’t lean into the turn enough. Only one time, last stage of Pirena, mostly it was demonstration for a large spectator crowd on trail that would not be used otherwise, there were hundreds of meters of continuous side hill in very icy conditions.

The sometimes horrifying trails and conditions in Alpirod did drive innovation but only afterward, around 2000, I tried to get a bit more edging with the sled designs, so rarely was it a problem. Then I found it was the attachment of the brake bar that prevented the few degrees of runner edging that would be needed. Using a larger bushing/hole in the mounting bracket 1/8″  or 2-3 mm larger OD than the pin was all that was needed, not an expensive and heavier ball joint. I much prefer simplicity in design and construction.

Ed Moody was a sled builder and musher who understood engineering. Here is a photo of his smaller model named for his daughter, Roz.

Sled Moody Roz

In the Kotzebue sprint race around 1997 there was bare ice on most of the triangle loop trail and strong winds paradoxically seemed to be mostly side winds. None of the sleds worked worth a #!@$. Roxie, Ed Dayton and I stood on the brakes most of the way to keep the line to the dogs tight, otherwise the sled might be perpendicular to the trail. We were so sore could hardly stand up after the race. A slew brake, like a skate edge to bite into the ice, might have helped.

More related:

https://everythingiknowaboutthatilearnedfrommysleddogs.wordpress.com/2012/06/09/oxymorons/

https://everythingiknowaboutthatilearnedfrommysleddogs.wordpress.com/2013/07/01/mushers-deserve-a-brake/