Malaria, Alzheimers, mitigate adverse cancer treatment chemotherapeutic effects, UTIs, methemoglobinemia
>On the other hand, positive side effects of MB acting as
a tonic have also been observed; these effects are possibly
due to an enhancement of mitochondrial activity.
Since 2007, however, we have had
difficulties in obtaining sufficient MB from pharmaceutical
companies for the clinical trials in West Africa. In
Germany, MB is no longer available even in pediatric
emergency rooms (Ludwig and Baethge, 2010). In addition,
it was claimed that the available MB preparations
were not pure enough, the major contaminants being
heavy metals, azure B, and water. By contrast, we regard
the prevailing requirements of USP and EP (listed for
instance in http://www.provepharm.com/analysis.php) as appropriate.
Taking heavy metal ions as examples, copper
and chromium are essential nutrients, and it is interesting
to compare their contents in a daily MB dose with their
contents in the ingredients of a standard meal. As a
conservative physician one is often concerned about the
overblown safety requirements of postmodern medicine
which too often prevent health- or even life-saving measures.
MB is spontaneously
oxidized by molecular oxygen (O2) to give toxic
reactive oxygen species (ROS) like superoxide or hydrogen
peroxide while MB is formed again. In this way MB is
available for the next cycle; it acts — in a functional unit
together with flavoenzymes and molecular oxygen — as a
recycling catalyst against infectious organisms (Fig. 1).
Apart from medical applications, this is the basis for using
MB as a disinfectant (Clark et al., 1925), for example as a
fungicide in aquariums (see, e.g., http://www.americanaquariumproducts.com).
(“Even at the loo we see, we pee, navy blue”)-Ditty from WWII when used as anti-malaria drug