BDNF-big dogs need food?
Buddha Does Not Flinch! And how to increase your own unflinching “Buddha,” brain derived neurotrophic factor, that is.
What’s on your mind, Facebook asks? BDNF! It is on my mind and in my mind. Yours too, the more the better. BDNF is a trending proxy-a metric for ways to improve mental health and brain function in Baby Boomers.
Exogenous BDNF treatment significantly improved neuromuscular transmission in all groups and NMTF in McAb3-treated rats was no longer different from control or McAb1-treated animals. We conclude that BDNF improves neuromuscular transmission in adult myasthenic rats. http://www.fasebj.org/content/24/1_Supplement/1064.13.short
A grab-bag of related info from ergo-log.com: >BDNF does to brain cells pretty much what steroids do to muscle cells. It helps them grow – not in physical size, but by helping brain cells to make new connections with each other.
>BDNF enables brain cells to grow and form new connections, so that the brain can absorb new information. DHA boosted the concentration of BDNF, and yes, this increase was larger when combined with exercise.
“The protective effects associated with elevations in brain carnosine appear to be related to a protection of BDNF expression in the hippocampus”, the researchers concluded. “The precise mechanism of how elevated carnosine concentrations support BDNF expression requires additional research. This appears to be the first study known to demonstrate a potential role of bèta-alanine as a dietary supplement for the treatment or prevention of post-traumatic stress disorder.”
Paradoxically, perhaps, nicotine increases BDNF. >Although nicotine has been shown to improve cognitive function in various studies, the mechanisms underlying acute nicotine treatment-induced neuroprotection remain incompletely understood. https://www.ncbi.nlm.nih.gov/pubmed/26259694
Considering the multifactorial nature of the biochemical links between physical activity and neurophysiology it is likely that there are many pharmacological mechanisms by which the beneficial actions of exercise can be effectively reproduced using chemical agents. Most studies to date have focused on brain-derived neurotrophic factor (BDNF) as a signaling target for the enhancement of neuronal function by exercise.
Understanding the molecular targets for exercise-induced regulation of neuroplasticity may lead to the development of novel therapeutic treatments for psychiatric and neurodegenerative disorders.
>Based on our current findings, we anticipate that fucoxanthin might exhibit
great therapeutic efficacy for the treatment of Alzheimer’s disease by acting on multiple targets,including inhibiting AChE and increasing BDNF expression. file:///root/Downloads/marinedrugs-14-00067.pdf
More grab-bags or call them tool boxes:
Linking brain and gut health:
Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?