Dope Or Die

Life is a competitive sport. Dope or lose, dope or die. Who would not take advantage of a method or substance to enhance performance with a moderate or acceptable tradeoff in harmful side effects? Only a dope would not dope in the strict definition of the word, using a method or substance to enhance performance. What competitive activities do not have some harmful side effects? In sports at the world level training and competition inevitably incur psychological and physiological costs.

Unfortunately, in sports the regulatory agencies such as WADA, the World Anti-Doping Agency, may go beyond rational proscription in their so-called fight against doping. And in sled dog sports the regulations are better characterized as irrational. Since eventually the lists of prohibited substances and methods must reflect community consensus, there may be hope on the horizon as more natural substances and methods are discovered and validated which might be presumed legal.

Altitude tents are a good example.

DMSO is another example, a substance not inherently harmful with natural anti-inflammatory properties but in some regulations prohibited for use, guilty by association with topical corticosteroids.

When is a non-steroidal anti-inflammatory substance not a Non-Steroidal Anti-Inflammatory Drug?
Mung bean seed coat and green tea:
http://www.lef.org/magazine/mag2014/jan2014_Turn-Off-the-Cytokine-Switch_01.htm

Turmeric and ginger compounds act as anti-inflammatory agents via inhibition of the eicosanoid inflammation cascade enzymes COX and LOX, the same as NSAIDS.
http://www.lef.org/magazine/mag2014/feb2014_Bio-Enhanced-TURMERIC-Compounds-Block-Multiple-Inflammatory-Pathways_01.htm

“Curcumin strongly blocked rheumatoid arthritis symptoms in animal studies by inhibiting joint inflammation as effectively as methotrexate,6 a drug with serious and sometimes fatal side effects.94 Curcumin improved arthritis scores in mice7 and suppressed osteoarthritis inflammation in dogs.95

Ginger extract blocked inflammatory mediators in a cell culture study—notably the signaling molecule prostaglandin E2—and reduced inflammatory swelling (edema). Researchers described the results as, “a potent suppressive effect on acute and chronic inflammation.”11

Clinical trials have now confirmed these results in humans.

Curcumin in doses of 500 milligrams daily was given to one group of rheumatoid arthritis patients. The NSAID drug diclofenac in doses of 50 milligrams daily was given to a second group. And a combination of the two was given to a third group. The group receiving curcumin-only had the greatest reduction in joint pain and swelling, with no adverse effects. By contrast, nearly 14% of participants in the drug-only group dropped out due to adverse effects!8”

95.Colitti M, Gaspardo B, Della Pria A, Scaini C, Stefanon B. Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs. Vet Immunol Immunopathol. 2012 Jun 30;147(3-4):136-46.

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