Have Your Cake And Eat It Too

But eat it all at once, then go hungry for the rest of the day.

More evidence that how long you go between meals is a positive factor in health.

Title: Time restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high fat diet
Authors: Megumi Hatori, Christopher Vollmers, Amir Zarrinpar, Luciano DiTacchio, Eric A. Bushong, Shubhroz Gill, Mathias Leblanc, Amandine Chaix, Matthew Joens, James A. J. Fitzpatrick, Mark H. Ellisman, Satchidananda Panda

Salk study may offer drug-free intervention to prevent obesity and diabetes

Extended daily fasting overrides harmful effects of a high-fat diet

May 17, 2012

LA JOLLA, CA—It turns out that when we eat may be as important as what we eat. Scientists at the Salk Institute for Biological Studies have found that regular eating times and extending the daily fasting period may override the adverse health effects of a high-fat diet and prevent obesity, diabetes and liver disease in mice.

In a paper published May 17 in Cell Metabolism, scientists from Salk’s Regulatory Biology Laboratory reported that mice limited to eating during an 8-hour period are healthier than mice that eat freely throughout the day, regardless of the quality and content of their diet. The study sought to determine whether obesity and metabolic diseases result from a high-fat diet or from disruption of metabolic cycles.

“It’s a dogma that a high-fat diet leads to obesity and that we should eat frequently when we are awake,” saysSatchidananda Panda, an associate professor in the Regulatory Biology Laboratory and senior author of the paper. “Our findings, however, suggest that regular eating times and fasting for a significant number of hours a day might be beneficial to our health.”

More specifics for daily fasting here:
Regarding meal or snack intervals for racing sled dogs:
Gary Paulson had the notion that dogs would run better with more energy if they snack frequently and regularly relatively small amts, just the same as Tour de France bike racers, though not the same snack ingredients. I agreed with him when he first talked to me about it; I had discovered that even in a two hour race like The Pas my dogs were more competitive if I stopped for the three minutes +/- to give them a quick snack. I experimented with fish, ice cubes containing liver and other ingredients, what I called pupsicles. I would make up the downtime in The Pas within 15-20 minutes usually. Sometimes sooner than that. Unanswered questions whether it was energy from the food calories (unlikely) water for hydration and/or psychological stress reduction.Bob Fritz’ Peak Performance powder seemed to address many of those mechanisms. Gary thought that each dog had an optimum snack interval so that the musher had to determine the lowest common denominator of the team or the short interval dogs would fail. Typically 50 minutes to an hour and a half, maybe more for slower pace according to the type of race.
Stress is like a lever, and current physiological and mental state, the terrain, establish the position of the fulcrum for better and worse, determining how much functional advantage or disadvantage stress has in the final result. Eustress is the level of stress that stimulates growth and health. Distress is excess stress with net harmful effects. The factor determining whether stress is good or bad may often be the mental state of the subject at the outset of the trial. For example, tell a person to run 100 yards in cold weather at their fastest speed. Or, tell them that their mother sitting in her car 100 yards away has a bomb in her lap that is going to explode if her son or daughter does not get their in time or similar circumstances and that same distance run could very well cause an asthma attack. Similarly I found that would happen to me if I lost my team and started chasing after it. I would need to suppress my anxiety…
Bob Fritz told me about the book Why Zebras Don’t Get Ulcers  many years ago. He also developed a sports supplement for dogs, Peak Performance that supported eustress vs. distress. The action of the sports supplement HMB illustrates the paradigm of distress>hypoglycemia>elevated catabolic hormones such as glucagon overriding normal metabolism, tearing apart muscle proteins for fast energy despite adequate energy in existing fat stores. For most athletes then and now the presence of lactate in Peak Performance was counter-intuitive or paradoxical. But Bob Fritz mentor George Brooks established the Lactate Shuttle and perhaps the name years before.

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